Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Alpha-synuclein aggregation / synaptic vesicle: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Microbial Metabolite-Mediated α-Synuclein Disaggregation | 0.448 | neurodegeneration | What are the mechanisms by which gut mic |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-01 | 20 hypotheses Top: 0.617
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Small molecule-driven NLRP3 inflammation inhibition via interplay between ubiqui [PMID:30966861] | ["Han X", "Sun S", "Sun Y", "Song Q", "Z | Autophagy | 2020 | 1 |
| Utility of Drosophila for studying hypoxia-inducible factor (HIF) in neurodegene [PMID:40976499] | Serebrovska Z, Xi L, Khetsuriani M, Prot | Brain research | 2025 | 0 |
| Revisiting Parkinson's disease definition and classification: insights from two [PMID:40906256] | ["Reyes N", "Pajo A", "Saranza G", "H\u0 | Journal of neural transmission | 2025 | 0 |
| Advancing Parkinson's diagnosis: seed amplification assay for α-synuclein detect [PMID:39760833] | ["Carrazana E", "Montalb\u00e1n-Guti\u00 | Molecular and cellular biochem | 2025 | 0 |
| MEK1/2 inhibitors suppress pathological α-synuclein and neurotoxicity in cell mo [PMID:40367191] | ["Wang H", "Wang Q", "Xu H", "Wu Y", "Ch | Science translational medicine | 2025 | 0 |
| Uncovering injury-specific proteomic signatures and neurodegenerative risks in s [PMID:40545497] | ["Mantash S", "Aboulouard S", "Dakik H", | Signal transduction and target | 2025 | 0 |
| Nucleolin inhibits α-synuclein to attenuate aconitine's neurotoxicity. [PMID:40482618] | ["Liu G", "Zuo W", "Zhang Z", "Lv W", "X | Phytomedicine : international | 2025 | 0 |
| The role of neuroimaging in Parkinson's disease. [PMID:34532856] | Bidesi NSR, Vang Andersen I, Windhorst A | J Neurochem | 2021 | 0 |
| Mitochondria and Parkinson's Disease: Clinical, Molecular, and Translational Asp [PMID:33074190] | ["Borsche M", "Pereira S", "Klein C", "G | Journal of Parkinson's disease | 2021 | 0 |
| High diagnostic performance of independent alpha-synuclein seed amplification as [PMID:34742348] | ["Russo M", "Orru C", "Concha-Marambio L | Acta neuropathologica communic | 2021 | 0 |
| Mitochondrial Dysfunction and Mitophagy in Parkinson's Disease: From Mechanism t [PMID:33323315] | ["Malpartida A", "Williamson M", "Narend | Trends in biochemical sciences | 2021 | 0 |
| The Role of α-Synuclein Oligomers in Parkinson's Disease. [PMID:33212758] | ["Du X", "Xie X", "Liu R"] | International journal of molec | 2020 | 0 |
| Kv1.3 modulates neuroinflammation and neurodegeneration in Parkinson's disease. [PMID:32597830] | Sarkar S, Nguyen HM, Malovic E | J Clin Invest | 2020 | 0 |
| Transneuronal Propagation of Pathologic α-Synuclein from the Gut to the Brain Mo [PMID:31255487] | ["Kim S", "Kwon S", "Kam T", "Panicker N | Neuron | 2019 | 0 |
| Neuropathology of genetic synucleinopathies with parkinsonism: Review of the lit [PMID:29124790] | ["Schneider S", "Alcalay R"] | Movement disorders : official | 2017 | 0 |
| Alpha-synuclein, Parkinson's disease, and Alzheimer's disease. [PMID:15109581] | ["Kim S", "Seo J", "Suh Y"] | Parkinsonism & related disorde | 2004 | 0 |